Dimethyl Sulfoxide
Apexbio Technology LLC Fidaxomicin 873857-62-6 10mM (in 1mL DMSO)
Fidaxomicin is a macrocyclic antibiotic derived from Actinomycetes functioning through inhibition of bacterial RNA polymerase by targeting the -subunit thereby interfering with bacterial RNA synthesis It exhibits specific antibacterial effects against Clostridium difficile suppressing toxin production and reducing disease recurrence in Clostridium difficile infections (CDI) Fidaxomicin has entered phase III clinical investigation for treatment of CDI Experimental results indicate an intravenous LD50 of approximately 200 mg/kg in rats reported inhibitory concentrations (IC50) against C difficile RNA polymerase range in the nanomolar scale It is utilized in research for studying bacterial transcription mechanisms and evaluating treatment strategies aimed at CDI
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, for molecular biology, Synonym: DMSO
Apexbio Technology LLC Lovastatin 75330-75-5 10mM (in 1mL DMSO)
Lovastatin (CAS 75330-75-5) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) a rate-controlling enzyme in cholesterol biosynthesis that mediates conversion of HMG-CoA to mevalonate In vitro assays show that lovastatin inhibits HMG-CoA reductase activity with IC50 values of 2 3 nmol/L in rat hepatocytes and 5 nmol/L in human hepatoma HepG2 cells By decreasing mevalonate and subsequent isoprenoid intermediates lovastatin reduces cellular proliferation and DNA synthesis It also enhances macrophage-mediated clearance of apoptotic cells at concentrations around 5 M Lovastatin serves as a useful tool in studies investigating lipid metabolism cellular proliferation pathways and related inflammatory processes
Apexbio Technology LLC Nicardipine HCl 54527-84-3 10mM (in 1mL DMSO)
Nicardipine HCl (CAS 54527-84-3) is a dihydropyridine-derived small molecule that functions primarily as a calcium-channel blocker through inhibition of voltage-dependent L-type calcium channels This mechanism prevents calcium ion influx causing vasodilation and decreased vascular resistance Widely applied in vascular biology and pharmacological research nicardipine hydrochloride serves as a useful tool to explore calcium-dependent processes cardiovascular pathophysiology and therapeutic strategies targeting calcium-mediated vascular conditions
Apexbio Technology LLC PF-562271 HCl 939791-41-0 10mM (in 1mL DMSO)
PF-562271 HCl (CAS 939791-41-0) is a potent ATP-competitive reversible inhibitor targeting focal adhesion kinase (FAK) and its homolog proline-rich tyrosine kinase 2 (Pyk2) It inhibits FAK and Pyk2 enzymatic activity with reported IC50 values of 1 5 nmol/L and 14 nmol/L respectively FAK is a non-receptor tyrosine kinase regulating cell adhesion migration and growth while Pyk2 shares structural similarity to FAK In animal models of cancer PF-562271 reduces tumor progression and metastatic spread with dose-dependent suppression of FAK phosphorylation (EC50 93 ng/mL) Thus PF-562271 serves as an important tool for investigating FAK/Pyk2-mediated pathways in oncology research
Apexbio Technology LLC C646 328968-36-1 10mM (in 1mL DMSO)
C646 (CAS 328968-36-1) is a small molecule pyrazolone derivative that functions as a selective competitive inhibitor of the histone acetyltransferase (HAT) activity of p300 It binds to the active site of p300 forming hydrogen bonds with residues Thr1411 Tyr1467 Trp1466 and Arg1410 C646 demonstrates a Ki of 400 nM and an IC50 of 1 6 M against p300 and also inhibits several p300 point mutants By specifically targeting p300-mediated protein acetylation C646 serves as a valuable research tool in studies investigating histone modification and gene transcription regulation
Apexbio Technology LLC Andarine 401900-40-1 10mM (in 1mL DMSO)
Andarine (S-4) is a selective androgen receptor (AR) antagonist with a Ki value of approximately 4 nM indicating strong receptor-binding affinity It functions by selectively targeting androgen receptors nuclear receptors involved in DNA-mediated transcription and gene expression regulation In vitro studies using AR-driven transcription assays illustrate Andarine s capacity to modulate AR activity at nanomolar concentrations Animal model studies in male Sprague-Dawley rats suggest Andarine administration induces a dose-dependent increase in tissues responsive to androgen activity including prostate gland seminal vesicles and levator ani muscle Due to its receptor specificity and manageable pharmacodynamics Andarine is widely investigated in biomedical research related to androgen receptor signaling pathways endocrine regulation and therapeutic responses involving AR-mediated mechanisms
Apexbio Technology LLC Pralatrexate 146464-95-1 10mM (in 1mL DMSO)
Pralatrexate (CAS 146464-95-1) is a small molecule inhibitor targeting dihydrofolate reductase (DHFR) with a Ki value of 45 nM DHFR mediates the reduction of dihydrofolate to tetrahydrofolate a critical cofactor in purine thymidylate and amino acid biosynthesis Pralatrexate exhibits high affinity for folylpolyglutamate synthetase (FPGS) and reduced folate carrier-1 (RFC-1) facilitating intracellular accumulation It demonstrates notable antiproliferative activity against various human cancer cell lines in vitro and reduces tumor growth in NSCLC xenograft models indicating its suitability for oncology research
Apexbio Technology LLC DBeQ 177355-84-9 10mM (in 1mL DMSO)
DBeQ (CAS 177355-84-9) is a selective and reversible inhibitor of the ATPase p97 (also known as VCP or Cdc48 in yeast) exhibiting an IC50 value of approximately 1 5 M p97 is an essential abundantly expressed hexameric AAA ATPase implicated in multiple cellular processes including endoplasmic reticulum-associated degradation (ERAD) mitochondrial-associated degradation autophagy maturation and regulation of transcription factors DBeQ inhibits p97 by specifically targeting its D1 and D2 ATPase domains leading to blockage of ERAD and autophagosome maturation Research applications of DBeQ include investigating protein homeostasis cancer biology and apoptosis induction mediated through caspases-3 and -9 activation
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 50mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, BioPerformance Certified, suitable for hybridoma, Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets USP and EP testing requirements.
Apexbio Technology LLC Mesoridazine(Synonyms: Serentil, Mesoridazine besylate, TPS-23), 10mM (in 1mL DMSO), CAS: 5588-33-0.
Mesoridazine (CAS 5588-33-0) is a dopaminergic antagonist primarily targeting dopamine D2 receptors (K d 19 nM) As an active metabolite of the atypical antipsychotic thioridazine mesoridazine demonstrates marked inhibitory effects on both pre- and postsynaptic dopamine receptors impacting dopamine and acetylcholine neurotransmission Furthermore mesoridazine engages histamine H1 (K d 1 8 nM) muscarinic acetylcholine (K d 69 nM) 1-adrenergic (K d 2 nM) and 2-adrenergic (K d 1600 nM) receptors Its receptor profile makes mesoridazine valuable for neuroscience research into antipsychotic mechanisms and neurotransmitter regulation
Apexbio Technology LLC AST-1306 897383-62-9 10mM (in 1mL DMSO)
AST-1306 (CAS 897383-62-9) is an inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptor tyrosine kinases In biochemical assays AST-1306 inhibits EGFR and HER2 kinase activity with IC50 values of 0 5 nM and 3 nM respectively It also demonstrates inhibitory activity against EGFR mutations such as T790M/L858R reducing receptor phosphorylation and downstream signaling in both cell-free and cellular systems In various animal tumor models including ErbB2-overexpressing and SK-OV-3 xenografts AST-1306 suppresses tumor growth and signaling pathways supporting its use in EGFR- and HER2-related oncology research
Apexbio Technology LLC SGI-1776 free base 1025065-69-3 10mM (in 1mL DMSO)
SGI-1776 free base (CAS 1025065-69-3) is an ATP-competitive inhibitor targeting Pim kinases a serine/threonine protein kinase family implicated in regulating cellular survival pathways It selectively inhibits all three isoforms Pim-1 Pim-2 and Pim-3 leading to decreased phosphorylation of downstream substrates involved in cell cycle regulation and apoptosis such as p21Cip1/WAF1 and Bad Cellular studies indicate that SGI-1776 induces G1 cell cycle arrest promotes apoptosis and overcomes chemoresistance mediated by multidrug resistance protein 1 (MDR1) in taxane-resistant prostate cancer cells
Apexbio Technology LLC Forskolin 66575-29-9 10mM (in 1mL DMSO)
Forskolin (CAS 66575-29-9) is a diterpenoid isolated from the plant Coleus forskohlii known to directly activate adenylate cyclase type I thereby elevating cellular cyclic AMP (cAMP) concentrations It exhibits an IC50 of approximately 41 nM against adenylate cyclase By increasing intracellular cAMP forskolin modulates signaling pathways involved in inflammation and oxidative stress reducing macrophage activation and subsequent production of thromboxane B2 and superoxide Forskolin has been explored in various experimental models and clinical contexts including cardiovascular disorders diabetes mellitus and asthma research